Ass. Prof. Steven Joniau, MD, PhD Consultant Urologist Dept of Urology University Hospitals Leuven Herestraat 49 3000 Leuven Belgium steven.joniau@uzleuven.be +32 16 34 69 45 +32 16 34 69 30 UZ Leuven | campus Gasthuisberg | Herestraat 49 | B - 3000 Leuven | www.uzleuven.be Education and Academic carreer Steven Joniau graduated in Urology in 2002 at the Catholic University of Leuven. In 2003, he was appointed full-time staff member at the Dept. of Urology, University Hospitals Leuven after a 1-year fellowship at the University Hospital of Wales, Cardiff, UK. In July 2012, he obtained his PhD in Medical Sciences entitled ‘High-risk localized prostate cancer: the role of surgery and the development of clinical outcome prediction models’. In 2013, he was appointed Assistant Professor at the Catholic University of Leuven. Expertise His principal field of interest is the management of urological cancers. He is heavily involved in urooncological surgery and the multidisciplinary approach of pelvic cancers. He also leads numerous research projects at the University Hospitals Leuven, which focus on lymph node staging in prostate cancer, surgical management and biomarker development of high-risk prostate cancer, the natural history of premalignant lesions of the prostate, chemoprevention of prostate and bladder cancer, minimally invasive treatment of renal cell cancer and prostate cancer, etc. Participation in boards and committees Steven Joniau is scientific secretary of the BVU (Belgische Vereniging voor Urologie), he is pastchairman of the Renal Cell Carcinoma Group of the Young Academic Urologists Working Party of the EAU, he is member of the EAU Guideline Panel on Prostate Cancer and the SIOG Prostate Cancer Guideline Panel. He was Scientific Committee member of European Multidisciplinary Meeting on Urological Cancers (EMUC), 2012, 2013 and of the Global Congress on Prostate Cancer (PROSCA) 2013. He is also a member of several international scientific societies: EAU, SIU (Société Internationale d’Urologie), SIOG (International Society of Geriatric Oncology) and EORTC GUCG (European Organisation for Research and Treatment of Cancer, Genito-Urinary Cancers Group). He is appointed Associate Editor of ‘The Journal of OncoPathology’. He is Editorial Advisory Board member of ‘The European Journal of Surgical oncology’, Editorial Board member of ‘The Open Prostate Cancer Journal’, ‘Archivo Italiano di Urologia e Andrologia’, ‘The Central European Journal of Urology’ and International Scientific Board member of ‘Archivos Españoles de Urología’. International recognition Steven Joniau has received several international awards, of which the First prize of the Urological Challenge Session, received at the 2010 European Urology Forum in Davos, Switzerland, the Crystal Matula Award 2011, received at the 2011 EAU annual congress in Vienna, Austria and the biannual Orion International Oncology Award 2011, received at the 2011 EAU annual congress in Vienna, Austria are the most prestigious. In the last 10 years, he has published >170 papers in peer-reviewed journals in the field of urooncology and minimally invasive surgery. He received the Prize for the Best Paper published on Clinical Research in the Urological Literature at the EAU annual congress in Stockholm. He authored several book chapters, he has been invited Faculty in over 85 international congresses and is a faculty member of the ESU (European School of Urology).

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OLEG SHAPIRO, MD FACS 6014 Westcliffe Road Jamesville, NY 13078 Home: (315) 314-7843 Mobile: (315) 416-3414 E-mail: shapiroo@upstate.edu PROFESSIONAL Vice-Chairman for Clinical Operations Department of Urology 7/2015-present Member-at-Large (New York), Northeast Section of the American Urologic Association 10/2015-present Member, College Affairs Committee of Medical College Assembly Upstate Medical University 3/2016-present Young Urologist Representative (USA), Northeast Section of the American Urologic Association 10/2013-10/2015 Organizing Committee for the 1st annual BHD symposium and 6th annual Kidney Cancer Conference, Upstate Medical University, Syracuse, NY 9/24/2015-9/26/2015 Associate Professor, Departments of Urology and Radiation Oncology-Upstate Medical University Syracuse, NY 12/2013-present Assistant Professor, Departments of Urology and Radiation Oncology-Upstate Medical University/VA Medical Center, Syracuse, NY 7/08-12/2013 Urology Clerkship Director 9/2012-5/15/2016 Social Program Chair, Northeastern AUA Annual Meeting, Saratoga Springs, NY 10/30/2013-11/3/2013 Secretary of International Russian Speaking Urological Society 10/2012-present Board of Directors, Northeast Section of the American Urologic Association 10/2013-present Vice-Chairman, Upstate Medical University Operating Room Operations Committee 5/2016=present BOARD CERTIFICATION: American Board of Urology 2/2010 FELLOWSHIP: American College of Surgeons EDUCATION Visiting Externship in Urologic Oncology 10/07-4/08 Fox Chase Cancer Center, Philadelphia, PA Preceptors: Dr. Robert Uzzo, Dr. Richard Greenberg Educational Grant: SUNY Upstate Medical University Chief Resident in Urology 7/2007-6/2008 Upstate Medical University, Syracuse, NY Resident in Urology 7/2004-6/2008 Upstate Medical University, Syracuse, NY General Surgery Intern/Resident (PGY 1, PGY 2) 7/2002-6/2004 Upstate Medical University, Syracuse, NY Doctor of Medicine 6/2002 Upstate Medical University, Syracuse, NY B.S.-Biology 9/1994-6/1998 Union College, Schenectady, NY HONORS AND AWARDS First Prize, Basic Research, 12th Annual Residents Competition, Skaneateles, NY 4/21/2007 Biology Department Award for Excellence 7/1998 Union College, Schenectady, NY Magna Cum Laude 6/1998 Union College, Schenectady, NY Phi Beta Kappa 6/1998 Union College, Schenectady, NY Dean’s List 7/1995-6/1998 Union College, Schenectady, NY National Honor Society 7/1994 Niskayuna High School, Niskayuna, NY PEER-REVIEWED PUBLICATIONS Woodford MR, Truman AW, Dunn DM, Jensen SM, Cotran R, Bullard R, Abouelleil M, Beebe K, Wolfgeher D, Wierzbicki S, Post DE, Caza T, Tsutsumi S, Panaretou B, Kron SJ, Trepel JB, Landas S, Prodromou C, Shapiro O, Stetler-Stevenson WG, Bourboulia D, Neckers L, Bratslavsky G, Mollapour M. Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors. Cell Reports, 2016 Feb 2; 14(4): 872-84 Daugherty M., Blakely S., Shapiro O., Vourganti S., Mollapour M., Bratslavsky G. Chromophobe Renal Cell Carcinoma is the Most Common Nonclear Renal Cell Carcinoma in Young Women: Results from the SEER Database. Journal of Urology, 2015 Nov 10 *Abouelleil M, Chelluri R, Duagherty M, Bratslavsky G, Shapiro O. In Obese Patients, the Distance Between Skin and Renal Collecting System Changes With the Position of the Patient From Supine to Prone. Journal of Endourology. 2015 May 6 *Blakely Stephen, Bratslavsky Gennady, Zaytoun Osama, Daugherty Mickey, Landas Steve, Shapiro Oleg. Preoperative cross-sectional imaging allows for avoidance of unnecessary adrenalectomy during RCC surgery. Urologic Oncology: Seminars and Original Investigations, 33(1) 2015 January *Byler Timothy K, *Leocadio Dean, Shapiro Oleg, Bratslavsky Gennady, Stodgell Christopher J, Wood Ronald W, Messing Edward M, and Reeder Jay E. Valproic Acid Decreases Urothelial Cancer Cell Proliferation and Induces Thrombospondin-1 Expression. BMC Urology, 2012 MS: 1558613551711322 *Stearns Gillian, *Cheng Jedsian, Shapiro Oleg, Nsouli Imad. Basal Cell Carcinom of the Prostate: A Case Report. Urology. 79(6):e79-80. *Dorsett Forrestall., *Hou Jack., Shapiro Oleg. Metastasis to the penis from rectal adenocarcinoma. Anticancer Research, 2012 May;32(5):1717-9. *Zhang Yachao, *Byler Timothy, Landas Steven, Ekroth Margaret, Shapiro Oleg. Large teratoma at aortic bifurcation: An unusual metastasis of testicular cancer. Can J Urol; 19(2):6201-6203, 2012 *Hou Jack, Landas Steve, Wang Ching, Shapiro Oleg. Instillation of mitomycin C after transurethral resection of bladder cancer impairs wound healing: an animal model. Anticancer Research. 31(3):929-32, 2011 DeLong JM, Shapiro Oleg, Moinzadeh Alireza. Comparison of laparoscopic versus robotic assisted partial nephrectomy: one surgeon’s initial experience. The Canadian Journal of Urology 17(3):5207-12, 2010 Jun. Shapiro Anna, Shapiro Oleg, Delongchamps Nicholas B, Bogart Jeffrey A, Haas Gabriel P, and De La Roza Gustavo. Autopsy Evaluation of a Prostate Cancer Case Treated with Brachytherapy. Anticancer Research 28:3909-3912 (2008). Shapiro Oleg, Welch Thomas R, Sheridan Maryellen, Streed Susan, Upadhyay Jyoti. Mixed Gonadal Dysgenesis and Denys-Drash Syndrome: Urologists Should Screen for Nephrotic Syndrome. The Canadian Journal of Urology 14(6):3767-9, 2007 Dec. Shapiro Oleg, Jones Karen, Wang Ching, Landas Steve, Haas Gabriel P. Risk of post-operative intravesical mitomycin C instillation following transurethral bladder tumor resection. The Canadian Journal of Urology 13(6):3317-3320, 2006 Dec. Shapiro Oleg, Singh Amar, Shapiro Anna, Shah Hemangini, Aronowitz Jesse. N, Bogart Jeffrey A, and Haas Gabriel P. Brachytherapy for Localized Prostate Cancer: Critical Assessment of Early Complications. Uroonkologia III(3):57-60, 2006 Oct. Jacobson Avi I, Amukele Samuel A, Marcovich Robert, Shapiro Oleg, Shetty R, Aldana JP, Lee Benjamin R, Smith Arthur D, Siegel Daniel N. Efficacy and morbidity of therapeutic renal embolization in the spectrum of urologic disease. Journal of Endourology 17(6):385-91, 2003 Aug. 5/2011 * Primary mentor INVITED SPEAKER Moderator for the Oncology Session at the iRUS Annual Meeting at the AUA Annual Meeting, San Diego, CA 5/2016 “GU Tract Trauma and Management of Trauma Patient”, Mayo Clinic Review in Anesthesia and Perioperative Medicine, University Hospital, Hue City, Vietnam 3/5/2016-3/6/2016 “Partial Adrenalectomy”, VHL Center Group Meeting, Upstate Medical University, Syracuse, NY 1/22/2016 Moderator for the Kidney Cancer Session at the 1st annual BHD symposium and 6th annual Kidney Cancer Conference, Upstate Medical University, Syracuse, NY 9/24/2015-9/26/2015 “Urinary Diversions-Outcomes, Complications and Quality of Life” and “Radiation After Prostatectomy: Case/Guidelines”, Association of Ukrainian Urooncologists Annual Meeting, Kiev, Ukraine, April 2015 Moderator for the Kidney/Testis Cancer session at the 19th annual Upstate Urology Resident Competition, April 12, 2014, Skaneateles New York “Prostate Cancer: Update 2013”, at the first annual meeting of the Association of Young Urologists of Russia, Moscow, Russia, October 2013 Moderator for the live laparoscopic radical prostatectomy at the first annual meeting of the Association of Young Urologists of Russia, Moscow, Russia, October 2013 “Minimally Invasive Treatment Options for Patients with BPH”, and “Genitourinary Trauma: The American Experience”, and “Medical and Surgical Treatment of Renal Calculus Disease”, at the Association of Oncourologists of Ukraine Scientific and Practical Conference, Kiev, Ukraine, April 2013. “New Technology in Urooncology”. 1st Annual Meeting of Urologic Oncologists of CIS. Kiev, Ukraine, 4/6/12-4/7/12 “Genitourinary Trauma: Radiologic Evaluation”, “Genitourinary Trauma: Upper Tract”, “Genitourinary Trauma: Lower Tract”. Al-Ahsa, Kingdom of Saudi Arabia, 5/15/12-5/16/12 PRESENTATIONS Michael Daugherty, Michael Daneshvar, Oleg Shapiro. Cancer-Specific Survival Is Not Affected By Histology Of T1 Tumors Undergoing Partial Nephrectomy. Presented by Dr. Michael Daugherty at the AUA National Meeting, San Diego, CA 5/2016 (Podium) Poster: Ambika Eranki, Oleg Shapiro, Rohin Mehta, Timothy Endy. Urinary Bladder Bilharziasis in a Somali Refugee: An Imported Case from the Jubba River Valley in Somalia; American Society of Tropical Medicine and Hygiene Annual Meeting, Philadelphia, PA 10/2015 Michael Daugherty, Gennady Bratslavsky, Oleg Shapiro. Are Lymph Node Dissections Being Performed In Patients With Biopsy Proven Gleason 6 Disease-Analysis of the SEER Database. Presented by Dr. Michael Daugherty at the Northeastern AUA Annual Meeting, Amelia Island, FL, 11/13/2014-11/16/2014 and at the AUA Annual Meeting, New Orleans, LA 5/2015 (Podium) Abouelleil Mourad, Daugherty Michael, Chelluri Raju, Bratslavsky Gennady, Shapiro Oleg. In Obese Patients, the Distance Between Skin And Renal Collecting System Changes With the Position of the Patient From Supine to Prone: The Story of the Fat. Presented by Dr. Abouelleil at the Upstate New York Urological Association 19th Annual Urology Resident Research Day, Skaneateles, New York, April 12, 2014 and AUA Annual Meeting, Orlando, FL 5/2014 (Moderated Poster) Daugherty Michael, Singer Eric, Metwalli Adam, Shapiro Oleg, Bratslavsky Gennady, Vourganti Srinivas. Stromal Testis Tumors Exhibit Worse Cancer-Specific Survival Compared to Germ Cell Testis Tumors In All Stage Categories: An Analysis of the SEER Registry. Presented by Dr. Daugherty at the Upstate New York Urological Association 19th Annual Urology Resident Research Day, Skaneateles, New York, April 12, 2014 and AUA Annual Meeting, Orlando, FL 5/2014 (Moderated Poster) Poster: Byler Timothy, Woodford Mark R, Messing Edward M, Bratslavsky Gennady, Shapiro Oleg, Reeder Jay E. Valproic Acid decreases TSP-1 expression in a mouse model of superficial bladder cancer: Northeastern Section of the American Urologic Association Annual Meeting, Annual Meeting, Saratoga Springs, NY 10/31/2013-11/3/2013 Byler Timothy, Wood Ronald W, Messing Edward M, Bratslavsky Gennady, Shapiro Oleg, Reeder Jay E. Valproic acid reduces tumor growth in a mouse model of superficial bladder cancer, presented by Dr. Byler at the Upstate New York Urological Association 18th Annual Urology Resident Research Day, Skaneateles, New York, April 20, 2013. Poster: Blakely Stephen, John Ivy Shraga Sarrina, Zaytoun Osama, Shapiro Oleg, Landas Steve, Bratslavsky Gennady; “Nephrosclerosis is Common in Young Patients With RCC: Potential Implications For Increasing Role of Renal Preservation”; AUA Annual Meeting, San Diego, CA 5/2013 (Moderated Poster) Poster: Byler Timothy, Wood Ronald W, Messing Edward M, Shapiro Oleg, Bratslavsky Gennady, Reeder Jay E; “Valproic Acid Reduces Tumor Growth in a Mouse Model of Superficial Bladder Cancer” AUA Annual Meeting, San Diego, CA 5/2013 (Moderated Poster) Poster: Blakely Stephen, Zaytoun Osama, Daugherty Michael, Landas Steve, Bratslavsky Gennady, Shapiro Oleg; “Adrenal Involvement in RCC: Avoiding Unnecessary Adrenalectomy” Northeastern AUA Annual Meeting, Niagara Falls, ON, Canada, 9/2012 (Moderated Poster) Zaytoun Osama, Blakely Stephen, Aboulleil Mourad, Daugherty Michael, Shapiro Oleg, De La Roza Gustavo, Landas Steve, Bratslavsky Gennady “Association of Multifocality With Different Histological Subtypes of Renal Cortical Tumors” Northeastern AUA Annual Meeting, Niagara Falls, ON, Canada, 9/2012 Poster: Shapiro Oleg, Wang Ching Y, Haas Gabriel P; “Instillation of Mitomycin C After Transurethral Resection of Bladder Cancer Impairs Wound Healing: An Animal Model”; AUA Meeting, Orlando, FL, 5/19 2008 (Moderated Poster) “Post-TURBT Mitomycin C instillation to decrease tumor re-implantation: Impaired wound healing?”; 12th Annual Residents Competition, Skaneateles, NY, 4/21 2007 “Post-TURBT Mitomycin C instillation to decrease tumor re-implantation: Impaired wound healing?”; St. Lawrence Urological Group Meeting, Quebec, Canada, 1/26-1/28 2007 Poster: Shapiro Oleg; “Initial Experience with the Male Sling Using Composite Graft for Treatment of Stress Urinary Incontinence in Post-Prostatectomy Patients”; Northeastern Section of the American Urological Association Annual Meeting, Ottawa, Canada, 9/7-9/9 2006 (Moderated Poster) Poster: Shapiro Oleg; “The Cost-Effectiveness of Suburethral Male Sling For Stress Urinary Incontinence Versus Artificial Urinary Sphincter 800”; Northeastern Section of the American Urological Association Annual Meeting, Ottawa, Canada, 9/7-9/9 2006 (Moderated Poster) Shapiro Oleg; “Testicular Epidermoid Cyst: An Unusual Presentation”; Case Presentation for “Stump the Professors” Session, Northeastern Section of the American Urological Association Annual Meeting, Ottawa, Canada, 9/7-9/9 2006 Shapiro Oleg; “Initial Experience with the Male Sling Using Composite Graft for Treatment of Stress Urinary Incontinence in Post-Prostatectomy Patients”; 11th Annual Residents Competition, Skaneateles, NY, 4/29 2006 Shapiro Oleg; “Initial Experience with the Male Sling Using Composite Graft for Treatment of Stress Urinary Incontinence in Post-Prostatectomy Patients”; St. Lawrence Urological Group Meeting, Quebec City, Canada, 2/3-2/5 2006 Shapiro Oleg; “Brachytherapy for Localized Prostate Cancer: Upstate Medical University Experience”; 10th Annual Residents Competition, Skaneateles, NY, 4/16 2005 Shapiro Oleg; “Brachytherapy for Localized Prostate Cancer: Upstate Medical University Experience”; St. Lawrence Urological Group Meeting, Quebec, Canada, 2/20-2/22 2005 LOCAL PRESENTATIONS: “Urologic Oncology and BPH”, Medical Student II Lecture, Upstate Medical University, Syracuse, NY, 1/29/2016 “GU Trauma, High Yield”, Department of General Surgery, Upstate Medical University, Syracuse, NY, 1/27/2016 “Small Renal Masses: Where Do We Stand?”, Division of Nephrology Grand Rounds, Syracuse, NY, 9/22/2015 “PSA Controversy and Case Discussion”, Medical Student II lecture, Upstate Medical University, Syracuse, NY, 1/27/2015 “Metastatic Renal Cell Carcinoma”, Medical Student I Lecture, Upstate Medical University, Syracuse, NY, 4/24/2014 “Urology for the General Surgeon”, Department of General Surgery, Upstate Medical University, Syracuse, NY, 4/16/2014 “Urology for the General Surgeon”, Department of General Surgery, Upstate Medical University, Syracuse, NY, 4/15/2013 “Urology for the General Surgeon”, Department of General Surgery, Upstate Medical University, Syracuse, NY, 4/18/2012 “Genitourinary Trauma”, Department of General Surgery, Upstate Medical University, Syracuse, NY, 10/3/2012 “Management of Neurogenic Bladder”; Division of Spine Surgery, Department of Orthopedic Surgery, Upstate Medical University, Syracuse, NY, 12/18 2006 “Superficial Bladder Cancer: Intravesical Therapy and its Complications”; Grand Rounds Presentation, Upstate Medical University, Syracuse, NY, 12/7 2006 “Intersex: A Focus on CAH”; Grand Rounds Presentation, Upstate Medical University, Syracuse, NY, 3/2 2006 “Brachytherapy for Prostate Cancer: Overview”; Grand Rounds Presentation, Upstate Medical University, Syracuse, NY, 3/10 2005 ABSTRACTS: “Sticks and Stones”: A Collaborative Approach to Urolithiasis Nayyar Rahul, Das Krishna, Shapiro Oleg, Jawed Mohammad. Submitted to 2014 ARRS Annual Meeting. Blakely Stephen A, Zaytoun Osama, Shapiro Oleg, Landas Steve, De La Roza Gustavo, Bratsalvsky Gennady; “Management of Small Renal Masses: Is Percutaneous Biopsy Necessary?” Society of Urologic Oncology Annual Meeting 2012 Blakely Stephen, John Ivy, Sheraga Sarrina, Zaytoun Osama, Shapiro Oleg, Landas Steve, Bratslavsky Gennady; “Nephrosclerosis is Common In Young Patient With RCC: Potential Implications of Increasing Role of Renal Preservation”. Society of Urologic Oncology Annual Meeting 2012 Byler Timothy, Wood Ronald W, Messing Edward M, Bratslavsky Gennady, Shapiro Oleg, Reeder Jay E; “Valproic Acid Reduces Tumor Growth In a Mouse Model of Superficial Bladder Cancer”, Society of Basic Urologic Research Annual Meeting, 2012 Richter Samuel M, Aridgides Paul D, Shapiro Oleg, Aronowitz Jesse N, Bogart Jeffrey A. “Permanent pd-103 brachytherapy followed by external beam radiotherapy for localized prostate adenocarcinoma is well-tolerated and provides excellent biochemical control”. GU ASCO 2/2012 Blakely Stephen, Bratslavsky Gennady and Shapiro Oleg. “Adrenal Involvement In Renal Cell Carcinoma: Avoiding Unnecessary Adrenalectomy”. AUA Annual Meeting, Atlanta, GA 5/2012 Blakely Stephen, Zaytoun Osama, Shapiro Oleg, Landas Steve, De La Roza and Bratslavsky Gennady; “Management of small renal masses: Is percutaneous biopsy necessary?”. Northeastern AUA Annual Meeting, Niagara Falls, ON, Canada 9/2012 Omarbasha Bashar, Shapiro Oleg. Initial Experience with the Male Sling Using Composite Graft for Treatment of Stress Urinary Incontinence in Post-Prostatectomy Patients (Abstract). The Canadian Journal of Urology 13(4):3222, 2006 August Shapiro Oleg, Omarbasha Bashar. The Cost-Effectiveness of Suburethral Male Sling For Stress Urinary Incontinence Versus Artificial Urinary Sphincter 800 (Abstract). The Canadian Journal of Urology 13(4):3222, 2006 August CHAPTERS “Renal Oncocytoma”, Shapiro Oleg, Stearns Gillian, 5-Minute Urology Consult, 3rd Edition, 2015 “Genetic Diseases”, Shapiro Oleg, Bratslavsky Gennady, Encyclopedia of Genetics, 2nd Edition, 2013 “Congenital Conditions”, Bratslavsky Gennady., Shapiro Oleg, Riddell John VB, Encyclopedia of Genetics, 2nd Edition, 2013 “Percutaneous Nephrolithotomy”, Cheng Jedsian and Shapiro Oleg, Urologybook.com (video chapter), 2012 “Circumcision in the Adult”, Byler Timothy and Shapiro Oleg, Urologybook.com (video chapter), 2012 LITERATURE PEER REVIEWER Urology (Gold Journal) 5/14-present Canadian Journal of Urology 5/07-present Frontiers in Genitourinary Oncology 1/12-present INVESTIGATOR Impact of Valproate on Angiogenesis And Histone Deacetylation in Bladder Cancer ROLE: Principal Investigator BEGIN DATE: 12/21/2011 END DATE: Ongoing ACCRUAL: 45 patients A Phase II, Open-Label, Controlled, Randomized Study of the CDX-1307 Vaccine Regimen as Neoadjuvant and Adjuvant Therapy in Patients with Newly Diagnosed Muscle-Invasive Bladder Cancer Expressing HCG- SPONSOR: Celldex Therapeutics, Inc. PRINCIPAL INVESTIGATOR: Imad Nsouli, M.D. ROLE: Co-Investigator EFFORT: 5% BEGIN DATE: August 1, 2010 END DATE: July 30, 2015 An International Phase 3 Randomized Trial of Autologous Dendritic Cell Immunotherapy (AGS-003) Plus Standard Treatment of Advanced Renal Cell Carcinoma (ADAPT) SPONSOR: Argos Therapeutics ROLE: Associate Investigator PRINCIPAL INVESTIGATOR: Gennady Bratslavsky, M.D. GRANT AMERICAN CANCER SOCIETY INSTITUTIONAL RESEARCH GRANT PRINCIPAL INVESTIGATOR: Oleg Shapiro, M.D. TITLE: Impact of Valproate on Angiogenesis and Histone Deacetylation In Bladder Cancer 9/2011-present FINANCIAL: $25,000 COMMUNITY PRESENTATIONS “Kidney Cancer: Diagnosis and Treatment”: American Cancer Society Relay for Life Event, Watertown, NY 7/2011 “The Significance of Elevated PSA”: 2nd Year Medical Student Lecture Syracuse, NY 1/2011 “Basics of Prostate Cancer”: 1st Year Medical Student Lecture Syracuse, NY 4/2010 “Kidney Cancer: Diagnosis and Treatment”: University HealthLink Program, Syracuse, NY 2/2010 “Prostate Cancer: Basics of Diagnosis and Treatment”: Man to Man Group, Syracuse, NY 11/2009 COURSES University of Pittsburgh Oral Boards Review Course Phoenix, AZ 1/2010 AUA Board Review Course, Dallas, TX 6/2009 Cleveland Clinic Single-Port Laparascopy, NOTES and Endoluminal Surgery Summit, Cleveland, OH 5/2009 Surgical Intuitive Davinci Robot Training on Live Model, Hackensack, NJ, 4/9 2007 American Medical Systems Prosthetics Course for Urology Residents: Minnetonka, MN, 4/21-4/22 2006 Basic Science Course for Urology Residents: Charlottesville, VA, 6/6-6/9 2005 RESEARCH EXPERIENCE (NOT PUBLISHED) “The Effects of Mitomycin C on Bladder Healing After Tumor Resection”; Preceptors: Ching Y. Wang, PhD and Gabriel P. Haas, MD, Upstate Medical University, Syracuse, NY PROFESSIONAL ORGANIZATIONS International Russian Speaking Urological Society Society of Urologic Oncology American Urologic Association Northeast Section of the American Urologic Association American College of Surgeons Endourological Society CALGB HOSPITAL COMMITTEES Medical Executive Committee, University Hospital 1/2016-present Upstate Cancer Center Clinical Operations Committee 1/2016-present Upstate Medical University Robotic Surgery Committee 1/2012-present Upstate Medical University Operating Room Operations Committee 8/2013-present Upstate Medical University IRB Reviewer 9/2013-present Quality Officer, Department of Urology 9/2008-5/2013 LANGUAGES Russian Ukrainian (limited) INTERESTS Travel, reading, biking, soccer, tennis, table tennis

ANNA SHAPIRO, MD 6014 Westcliffe Road Department of Radiation Oncology Jamesville, NY 13078 SUNY Upstate Medical University (315) 278-3036 750 East Adams Street Syracuse, NY 13210 e-mail: shapiran@upstate.edu (315) 464-5276 Personal Birthplace: Kishinev, Moldova Education New York University, New York, NY Degree: B.A. Biology, Biochemistry, June 2000 Summa Cum Laude SUNY Upstate Medical University, Syracuse, NY Degree: M.D., May 2004 Post-Graduate Training Internship: Transitional: July 2004-June 2005 Saint Joseph’s Hospital Medical Center Syracuse, NY Residency: Radiation Oncology: July 2005-June 2009 SUNY Upstate Medical University Syracuse, NY Chief Resident: July 2008-June 2009 Visiting resident Radiation Oncology: March 2008-April 2008 Fox Chase Cancer Center, Philadelphia, PA MammoSite Clinical Training Program: September 2009 Gamma Knife Certification January 2010 University of Pittsburg Medical Center, Pittsburgh, PA TheraSphere Center of Excellence training program: January 2012 Northwestern University Chicago, IL Licensure and Certification New York active Diplomate, National Board of Medical Examiners June 2005 Diplomate, American Board of Radiology in Radiation Oncology June 2010 Grants: Carol Baldwin Breast Cancer Research Award PRINCIPAL INVESTIGATOR: Anna Shapiro, M.D. TITLE: Predictive Blood Tests for Severe Radiation Reactions in Breast Cancer Patients. 9/2005-2013 FINANCIAL: $50,000 Clinical Trials: 1. Prospective Assessment of Simulated Prone Whole-Breast Radiation Therapy versus Supine Whole-Breast Radiation Therapy with Respiratory Gating: A Dosimetric Comparison of Organs at Risk. Principal Investigator: Anna Shapiro, MD Co-Investigators: Samuel Richter MD, Katrina Stellingwerf, Dwaine Spence, Jeffrey Bogart, MD Status: Open to accrual. 2. RTOG 1112: Randomized Phase III Study of Sorafenib Versus Stereotactic Body Radiation Therapy Followed By Sorafenib in Hepatocellular Carcinoma Principal Investigator: Anna Shapiro, MD Status: Open to accrual. 3. RTOG 1005: A Phase III Trial of Accelerated Whole Breast Irradiation with Hypofractionation plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost for Early-Stage Breast Cancer Principal Investigator: Anna Shapiro, MD Status: closed Academic Appointments SUNY Upstate Medical University, Syracuse, NY Department of Radiation Oncology Assistant Professor July 2009-September 2016 Associate Professor September 2016-present Hospital Staff Appointments University Hospital, SUNY Upstate Medical University Syracuse, NY Active Staff, Radiation Oncology July 2009-present Crouse Hospital Syracuse, NY Active Staff, Radiology, Radiation Oncology Sept. 2009-present St. Joseph’s Hospital Health Center Syracuse, NY Active Staff, Radiology, Radiation Oncology Sept. 2009-present Oswego Hospital Oswego, NY Consulting Staff, Radiology, Radiation Oncology Sept 2009-present Veterans Administration Medical Center Syracuse, NY Active Staff, Radiology, Radiation Oncology Sept 2009-present Community General Hospital Syracuse, NY Consulting Staff, Radiation Oncology Sept 2009-present Society Memberships American Radium Society American Society for Therapeutic Radiology and Oncology Medical Society of the State of New York Onondaga County Medical Society Radiological Society of North America Upstate New York Society for Therapeutic Radiology and Oncology American Medical Association Committee Appointments: National Radiological Society of North America Scientific Program Committee 2010-present Committee Appointments: University Upstate Cancer Center Clinical Operations Committee, member 2016 Radiation Oncology Program Evaluation Committee, member 2013-present Radiation Oncology Clinical Competency Committee, member 2013-present Veterans Administration Medical Center Cancer Committee, member 2014-present Medical College Assembly Executive Counsel, member 2012-present College of Medicine Interview Committee, member 2009-present OB/GYN Chair Search Committee, member 2010 Radiation Oncology Quality Improvement Committee, member 2006-2008 Teaching Faculty Advisor Cayuga Upstate learning community 2014-present Mentor to 4 students from each of the four years in medical school Quarterly advisory meetings Monthly community-building activities Upstate Breast Education conference, speaker October 2015 SUNY Upstate Medical University Practice of Medicine Course-Proctor 2011-present Mentorship of radiation oncology residents Regular speaker for Radiation oncology residency educational curriculum Participant in multidisciplinary Breast Cancer program Regular speaker for Medical Oncology Grand Rounds Case management conference for Radiation Oncology residents and elective students: three days/week. Chart Rounds for Radiation Oncology residents: once/week. Multi-disciplinary Conferences: Participant in GI oncology tumor board: weekly Participant in Breast oncology tumor board: weekly National Scientific Meeting Moderator/Faculty/Invited Lectures/Panels Moderator, Radiation Oncology and Radiobiology - GI cancers: Radiological Society of North America, Chicago IL November 2010 Moderator, Radiation Oncology poster session, Radiological Society of North America, Chicago IL December 2011 Moderator, Radiation Oncology and Radiobiology - Breast cancer, Radiological Society of North America, Chicago IL December 2011 Moderator, Radiation Oncology and Radiobiology - Quality of life, Radiological Society of North America, Chicago IL December 2011 Moderator, BOOST: Breast—Integrated Science and Practice, Radiological Society of North America, Chicago, IL December 2012 Moderator, Radiation Oncology and Radiobiology - Outcomes, Radiological Society of North America, Chicago, IL December 2012 Moderator, Radiation Oncology poster session, Radiological Society of North America, Chicago, IL December 2012 Moderator, Stereostatic Radiosurgery and Stereostatic Body Radiation Therapy, American Radium Society, Las Vegas, NV May 2012 Moderator, BOOST: Breast—Integrated Science and Practice Session, Radiological Society of North America, Chicago IL, November 2013 Moderator, Radiation Oncology and Radiobiology: Outcomes, Radiological Society of North America, Chicago IL, November 2013 Keynote speaker, ISP: Radiation Oncology and Radiobiology: Breast, Radiological Society of North America, Chicago IL, December 2014 Moderator, BOOST: Breast—Integrated Science and Practice Session, Radiological Society of North America, Chicago IL, December 2015 Keynote speaker, ISP: Radiation Oncology and Radiobiology: Outcomes/Quality of Life I, Radiological Society of North America, Chicago IL, December 2015 Moderator, Breast cancer panel, 100th annual meeting American Radium Society, Philadelphia, PA April 2016 Ad hoc Reviewer BMC Cancer Diseases of the Esophagus Publications 1. Shapiro A, Gay HA, Hahn SS, Bogart JA, Shah H, Chung CT, Treatment Results for Non-Small Cell Lung Cancer Patients Presenting with Brain Metastases. J Radiat Oncol Biol Phys 69:S512-S513, 2007 2. Hsie MY, Chung CT, Hahn SS, Hodge CJ, Canute GW, Montgomery CT, Shapiro A. Quality of Life in Patients Treated with Repeat Gamma Knife Radiosurgery for Recurrent or Refractory Trigeminal Neuralgia. Int J Radiat Oncol Biol Phys 72:S224, 2008 3. Shapiro A, Shapiro O, Delongchamps N, Bogart JA, Haas G, de la Roza G. Autopsy evaluation of a prostate treated with brachytherapy. Anticancer Res 28:3909-3912, 2008 4. Shapiro A, Redmond M, Mitchell L, Chung CT, Shah H, Hahn SS, Bogart JA, Canute G. Repeated Stereotactic Radiosurgery for Recurrent Brain Metastases is Safe and Effective. Int J Radiat Oncol Biol Phys 75:S114-S115, 2009 5. Aridgides P, Bogart J, Shapiro A, Gajra A. PET-response guided treatment of Hodgkin’s Lymphoma: A review of the evidence and active clinical trials. Adv Hematol 2011:309237, 2011 6. Li W, Liu L, Shapiro A. Dosimetric Effects of Air Cavity Migration Through the MammoSite Multi-Lumen Balloon Treatments. Medical Phys 40: SU-E-T-347, 2013 7. Hudson, S. G. Halleran, D.R. Nevaldine, B. Shapiro, A. Hutchison, R.E. and Hahn, P.J. Microarray determination of Bcl-2 family protein inhibition sensitivity in breast cancer cells. Experimental Biology and Medicine 238, no. 2 (2013): 248-256 8. Prashant Upadhyaya, MD; Thomas Certo, MD; Kent O Hustad, MD; Mark E Costaldi, MD; Klaus Busam, MD; Bruce Smoller, MD; Stefania Morbidini-Gaffney, MD; Anna Shapiro, MD; Deepinder Singh, MD; Gloria J Morris, MD, PhD. 55-Year-Old Female with Estrogen-Receptor-Positive Scalp Lesion. Seminars in Oncology 42: e77–e82 2015 9. Emily Catherine Daugherty, M.D.; Michael R Daugherty, M.D.; Jeffrey A Bogart, M.D.; Anna Shapiro, M.D. Adjuvant Radiation Improves Survival in Older Women Following Breast Conserving Surgery for Estrogen Receptor Negative Breast Cancer. Accepted for publication in Clinical Breast Cancer Abstracts SS, Gay HA, Shalevich A, Bogart JA, Chung CT. The Prognosis and Treatment Results of Non Small Cell Lung Cancer Patients Presenting with Brain Metastases. American Radium Society 86th Annual Meeting, Napa Valley, CA. May 2004 Shapiro A, Gay HA, Hahn SS, Bogart JA, Shah H, Chung CT. Treatment Results for Non-small Cell Lung Cancer Patients Presenting with Brain Metastases. 49th Annual Meeting American Society of Therapeutic Radiology and Oncology, Los Angeles, CA, October 2007 Shapiro A, Chung CT, Bogart J, Bassano D, Shah H, Montgomery C, Hodge C, Canute G, Mitchell L, Hahn SS. Quality of life following Gamma Knife radiosurgery for treatment of trigeminal neuralgia. 14th International Meeting Leksell Gamma Knife Society, Quebec, Canada, May 2008 Hsie MY, Chung CT, Hahn SS, Shah H, Hodge CJ, Canute GW, Montgomery CT, Shapiro A. Quality of Life in Patients Treated with Repeat Gamma Knife Radiosurgery for Recurrent or Refractory Trigeminal Neuralgia. 50th Annual Meeting American Society for Therapeutic Radiology and Oncology, Boston, MA, September 2008 Shapiro A, Redmond M, Mitchell L, Chung CT, Shah H, Hahn SS, Bogart J, Canute G. Repeated stereotactic radiosurgery for recurrent brain metastases is safe and effective. 51st Annual Meeting American Society for Therapeutic Radiology and Oncology, Chicago, IL, November 2009 Hicks A, Canute G, Redmond M, Bassano D, Shapiro A. Repeat Gamma Knife Radiosurgery for Recurrent Brain Metastases from Breast or Lung Carcinoma. Poster of Distinction , American Radium Society, 92nd Annual Meeting, Cancun, Mexico May 2010 Aridgides P, Shapiro, A. Gama Knife radiosurgery for treatment of skull base meningiomas. 53rd Annual Meeting American Society for Therapeutic Radiology and Oncology Miami, FL. October 2011 Chowdhry V, Shapiro A, Hyder J. Tiewul T, Hahn SS, Chung CT, Treatment Patterns in Long Term Survivors of Non-Small Cell Cancer Presenting with Brain Metastasis. American Radium Society 94th Annual Meeting, Las Vegas, NV, April 2012 Aridgides P, Shapiro A. Gamma Knife Radiosurgery (GKS) is well-tolerated and provides meaningful disease control for patients with meningiomas secondary to childhood brain radiation therapy (RT), Leksell Gamma Knife Society Sydney, Australia 2012 Richter S, Aridgides P, Shapiro A. Permanent Pd-103 Brachytherapy followed by External Beam Radiotherapy for Localized Prostate Adenocarcinoma is Well-Tolerated and Provides Excellent Biochemical Control. Genitourinary Cancers Symposium, 2012. Li W, Liu L, Shapiro A. Dosimetric Effects of Air Cavity Migration Through the MammoSite Multi-Lumen Balloon Treatments. American Assiciation of Physicists in Medicine 55th Annual Meeting, Indianapolis, IN 2013. Shapiro A, Daugherty M, Bogart JA, Daugherty E, Adjuvant Radiation Improves Survival in Older Women Following Breast Conserving Surgery for Estrogen Receptor Negative Breast Cancer, 32nd annual Miami Breast Cancer Conference, Miami FL, February 2015 Best surgical poster award. Shapiro A, Finnegan V, Chowdhry V, Lee W, Stellingwerf K, Dosimetric Evaluation of Respiratory-Gated Radiotherapy for Left-Sided Breast Cancer American Radium Society 97th annual meeting, Kauai, HI May 2015 Richter S, Stellingwerf K, Spence D, May K, Banashkevich A, Shapiro A, Prospective Assessment of Simulated Prone Whole-Breast Radiation Therapy versus Supine Whole-Breast Radiation Therapy with Respiratory Gating: significant lung dose reduction with prone positioning. 100th annual meeting American Radium Society, Philadelphia, PA April 2016 Presentations Shapiro A, Aridgides P, Shah H, Chung CT, Bogart J, Hodge C, Montgomery C, Canute G, Bassano D, Mitchell L, Hahn SS. Gamma Knife radiosurgery for brain stem lesions: tumor control and patient outcomes. Oral presentation, American Radium Society 90th Annual Meeting, Dana Point, CA. May 2008. Aridgides P, Barz A, Bhavsar S, Mitchell L, Bogart J, Hahn S, Chung C, Shapiro A, Treatment of Large (>10cm3), Intracranial Meningiomas with Gamma Knife Radiosurgery is Effective but Associated with Increased Risk of Morbidity. Oral Presentation, American Radium Society 94th Annual Meeting, Las Vegas, NV. April 2012 Cupelo E, Aridgides P, Bogart J, Shapiro A. The impact of estrogen receptor status on treatment outcomes following gamma knife radiosurgery for brain metastases of primary breast cancer. Poster Presentation , San Antonio Breast Cancer Symposium, San Antonio, TX December 2012. V.A. Finnegan, S. S. Hahn , A. Shapiro, L. Mejico The Significance of Different Dose Fractionations in the Management of Optic Nerve Sheath Meningioma. Poster presentation American Radium Society, 96th annual meeting, St. Thomas, U.S. Virgin Islands, May 2014 Honors and Awards Humanitarian Award recipient Carol M. Baldwin Breast Cancer Research fund of CNY 2015 Teacher of the Year Award recipient Department of radiation oncology residents 2009-2010 SUNY Upstate Medical University Best of ASCO travel award recipient 2007

CURRICULUM VITAE Prof. Dr. Gert De Meerleer, University Ghent Responsible physician for IMRT and IMAT for pelvic tumours (urologic and gynaecologic tumours) STUDIES Graduated as MD in 1994 at Ghent University, Belgium • Postgraduate training in radiation oncology 1994-1999 University Hospital, Gent, Belgium, Department of Radiotherapy Aug. 1999 Board Certification as Radiotherapian - Oncologist by the Belgian Ministry of Public Health. • Additional training 1999-2000 Resident at the department of Radiotherapy and Oncology, O.L.V. Hospital, Aalst, Belgium • Doctoral (Ph.D.) thesis May 2000 Multileaf collimation and intensity modulated radiotherapy: initial clinical applications. Ghent University, Belgium. SCIENTIFIC AWARDS 2000-2006 Post-doctoral (post-PhD.) fellow of the \"Fonds voor Wetenschappelijk Onderzoek - Vlaanderen\" 1995 Spring-Meeting of the Belgian Society of Radiotherapists and Oncologists, Junior Presentations, First price. 1997 Spring-Meeting of the Belgian Society of Radiotherapists and Oncologists, Junior Presentations, Third price. 1998 Spring-Meeting of the Belgian Society of Radiotherapists and Oncologists. Junior Presentations, Second price. 1998 ESTRO Physics Award, first price. 2005 Clinical Research Grant donated by the “Belgische Federatie tegen Kanker” for a value of 130.000 Euro. 2006 Clinical Research Grant donated by the “Centrum voor Gezwelziekten” for a value of 25.000 Euro. - 2 - FUNCTIONS AND NOMINATIONS - Staff member of the department of Radiotherapy, University Hospital Gent. Responsible physician for the urologic and gynaeco-pelvic malignancies. - Director of the ESTRO multidisciplinary teaching course on prostate cancer. - Co-ordinator of a research fund of the ‘Belgische Federatie tegen Kanker’. This fund finances parts of the fundamental and clinical research concerning prostate cancer at Ghent University Hospital. - Co-ordinator of a research fund of the ‘Centrum voor Gezwelziekten’. This fund finances parts of the fundamental and clinical research concerning prostate and cervical cancer at Ghent University Hospital. - Teacher at the ESTRO teaching course on image-guided radiotherapy. HOBBIES Piano playing (jazz); travelling and wildlife viewing; literature. PUBLICATIONS Registered, peer-reviewed (A1) publications: 30 from which about 60% deal with IMRT and/or image-guided radiation therapy. References 1. De Meerleer G, Vakaet L, De Gersem W, De Wagter C, De Naeyer B, De Neve W. Radiotherapy of prostate cancer with or without intensity modulated beams: a planning comparison. Int J Radiat Oncol Biol Phys 2000; 47: 639-648. 2. De Meerleer G, Vakaet L, De Gersem W, Villeirs G, De Neve W. Direct segment aperture and weight optimisation for intensity modulated radiotherapy of prostate cancer. Strahlenther Onkol 2004; 3: 136-143. 3. De Meerleer G, Villeirs G, Vakaet L, Delrue J, De Neve W. The incidence of inclusion of the sigmoid colon and small bowel in the planning target volume in radiotherapy for prostate cancer. Strahlenther Onkol 2004; 180: 573-581. 4. De Meerleer G, Vakaet L, Meersschout S, Villeirs G, Verbaeys A, Oosterlinck W, De Neve W. Intensity Modulated Radiotherapy as primary treatment for prostate cancer: acute toxicity in 114 patients. Int J Radiat Oncol Biol Phys 2004; 60: 777-787. 5. Villeirs G, De Meerleer G, Verstraete K, De Neve W. Magnetic resonance assessment of prostate localization variability in intensity-modulated radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 2004; 60: 16111621. 6. De Meerleer G, Villeirs G, Bral S, Paelinck L, De Gersem W, Dekuyper P, De Neve W. The magnetic resonance detected intraprostatic lesion in prostate cancer: planning and delivery of intensity-modulated radiotherapy. Radiother Oncol 2005; 75: 325-333. - 3 - 7. Villeirs G, Van Vaerenbergh K, Vakaet L, Bral S, Claus F, De Neve W, Verstraete K, De Meerleer G. Interobserver delineation variation using CT versus combined CT + MRI in intensity-modulated radiotherapy for prostate cancer. Strahlenther Onkol 2005; 75: 325-333. 8. De Meerleer G, Fonteyne V, Vakaet L, Villeirs G, Denoyette L, Verbaeys A, Lumen N, De Neve W. Intensity- modulated radiation therapy for prostate cancer: late morbidity and results on biochemical control. Radiother Oncol 2007; 82: 160-166. 9. Fonteyne V, De Neve W, Villeirs G, De Wagter C, De Meerleer G. Late radiotherapy-induced lower intestinal toxicity (RILIT) of intensity-modulated radiotherapy for prostate cancer: the need for adapting toxicity scales and the appearance of the sigmoid colon as co-responsible organ for lower intestinal toxicity. Radiother Oncol 2007; 84: 156-163. 10. Villeirs GM, De Meerleer GO. Magnetic resonance imaging (MRI) anatomy of the prostate and application of MRI in radiotherapy planning. Eur J Radiol 2007; 63: 361-368. 11. Fonteyne V, Villeirs G, Speleers B, De Neve W, De Wagter C, Lumen N, De Meerleer G. Intensity-modulated radiotherapy as primary therapy for prostate cancer: report on acute toxicity after dose escalation with a simultaneous integrated boost on the intraprostatic lesion. Int J Radiat Oncol Biol Phys 2008; In Press.

CURRICULUM VITAE January 2013 Professor GURAM KARAZANASHVILI M.D., ScC, Sc.D. Founder & Chief of Urology SJC “Modern Medical Technologies” 5, Lubliana st. Tbilisi-0159, Goergia Fax: +995 322 604140 Tel: +995 322 234023 Born: June 11, 1964 (Tbilisi, Georgia) Sex: male Citizenship: Georgia Marital Status: Married - Daughter (Born: June 20,1993), Sun (Born: September 1,1998), Sun (Born: June 25, 2004) EDUCATION AND TRAINING • Clinical fellowship – Laparoscopic Urology, Department of Urology, Vivantes Kliniken Berlin (Chief-Prof. J. Roigas), Germany 08.2012 • Research and clinical fellowship- Department of Urology, University Hospital Bonn (Chief-Professor Stefan Műller), Germany, 01.11.2005-31.12.2006 • Academic exchange – between American and European Urological Associations (Mayo Clinic, Duke University, Chicago University, Vanderbilt University) IV-V. 2003, USA • Reasearch fellowship – Urology Department of University Hospital Malmö (Chief-Prof. P-A. Abrahamsson) 01.09.2000-30.04.2001, Malmö, Sweden • Clinical Internship – Urology department of University of Vienna (Chief – Professor M. Marberger), 02.09.2003-26.09.2003, Vienna, Austria • Research fellowship - Urology Department of University Hospital Bonn (Chief-Prof. S.Müller), 01.10.1997-31.01.1998, Bonn, Germany • Clinical Internship - Urology Department of University Hospital Offenbach am Main (Chief- Prof. U.W. Tunn), 01.10.1996-31.12.1996, Offenbach am Main, Germany • Clinical Internship - Urology Department of the University Hospital Nijmegen (Chief- Prof. F.M.J. Debruyne), 24.09.1995-02.12.1995, Nijmegen, The Netherlands • Post Graduate Course - Urology Department of Central Institute for Advanced Medical Studies (Chief-Prof. V.S. Riabinski), 1989-1991, Moscow, USSR • Residency Training - Urology Department of Central Institute for Advanced Medical Studies (Chief-Prof. V.S. Riabinski), 1987-1989, Moscow, USSR • Internship - Department of Abdominal Surgery of Central republic Clinical Hospital (Chief-Prof. T. Achmeteli), 25.08.1987-06.01.1988, Tbilisi, USSR • University - Tbilisi State Medical University (Honors Diploma), 1981-1987, Tbilisi, USSR • College - Physic-Mathematics School of V.M. Komarow (Honors Diploma), 1978-1981, Tbilisi, USSR EMPLOIMENT • Chief of Urology – Clinic of SJC “Modern Medical Technologies”, since – 2012 • Full Professor – University “Geomedi”, since 2012 • Chief of urologic clinic - Medical Diagnostic Center of Tbilisi State University, since – 01.01.2007-2012, Tbilisi, Georgia • Director General - Medical Diagnostic Center of Tbilisi State University, since –2004-2011, Tbilisi, Georgia • Associate Professor of Urology - Tbilisi State Medical University, 2006-2009, Tbilisi, Georgia • Professor - Department of Urology of Tbilisi State Medical University, 2005-2006, Tbilisi, Georgia • Associate Professor - Department of Urology of Tbilisi State Medical University, 2004, Tbilisi, Georgia • Assistant Professor – Department of Urology of Tbilisi State Medical University, 2001-2004, Tbilisi, Georgia • Senior Scientific Staff member – Institute of Clinical and Experimental Medicine of Tbilisi State Medical University,1993-1999, Tbilisi, Georgia • Urologist - Department of Urology Central Republic Clinical Hospital, 1991 – 2001, Tbilisi, Georgia MEMBERSHIP IN PROFESSIONAL MEDICAL SOCIETIES OR ASSOCIATIONS • International Member of American Urological Association, since 2010 • Member of Clinical Research Office of European Association of Urology, since 2008 • Advisory board member – Association of German Scholarship Holders, since 2008 • Active Member - European Association of Urology, since 1996 • Member - Georgian Association of Urology, since – 1992 RESEARCH ACTIVITIES • Reviewer of platinum journal -“European Urology”, since 2003 • Doctor of Sciences (Sc.D.) - Medical Qualification Council M 14. 40 # 1 at Tbilisi State University, 2002 • Urologist of the Highest Qualification - Attestation Committee of the Health Ministry of Georgia, 1994 • Candidate of Medical Sciences (Sc.C.) - Supreme Attestation Committee of USSR, Moscow 1991 SPECIAL AWARDS • Georgian National Award – for outstanding achievements on prostate Cancer research 25.05.2011 • Alexander von Humboldt Foundation, Georg Forster Research Fellowship, 2005-2006 • American Urological Association - European Association of Urology International Exchange Program - :”AUA Tour, 2003” • Swedish Institute Research Scholarship, 01.09.2000 – 31.04.2001 • Best Poster Presentation Prize - PACIOU V (Progress and Controversies in Oncological Urology V), Chairman - Professor F. Schöder, Rotterdam, 15-17 October, 1998 • German Academic Exchange Service (DAAD) Research Scholarship, 01.10.1997 – 31.01.1998 • German Society of Urology (DGU) Clinical Scholarship 01.10.2006 – 31.12.2006 • Tbilisi State Medical Institute Vl. Jgenty Scholarship, 01.09.1985 – 01.09.1987 LAENGUIDGE SKILLS English, German, Russian, Georgian

Curriculum vitae Name: Gakis Prename: Georgios Title: Professor of Urology, M.D., F.E.B.U. ____________________________________________________________ Occupational career: 2012-date Staff member, Dept. of Urology, University Hospital Tübingen 2011-2012 Urologist, Dept. of Urology, University Hospital Tübingen 2011 Board Certification of Urology 2011 Fellow of the European Board of Urology” 2006-2011 Resident, Dept. of Urology University Hospital Tübingen 2006- Resident, Dept. of General Surgery, University Hospital Munich-Grosshadern, Germany Memberships in international committees and associations: 2013-date First author of the EAU Guidelines on Primary Urethral Carcinoma 2012-date Member of the der EAU Guidelines Group on Muscle-invasive and Metastatic Bladder Cancer 2016 Section leader of the S3-German Guidelines on Non-muscle invasive Bladder Cancer 2014 Member of the ICUD-EAU Consensus Meeting, Treatment of Urological malignancies (Bladder Cancer) 2013 Member of the ICUD-SIU Guidelines on Upper Tract Urothelial Carcinoma 2013 2011 Member of the ICUD-EAU Guidelines Group 2012 (Committee 6: muscle-invasive bladder cancer) Peer-reviewed publications in Pubmed (JCR): 137 (09/2014) Current activities as editor in scientific journals: PLOS One (Academic Editor), Bladder Cancer (Associate Editor for Reviews) Current activities as reviewer in scientific journals/institutions: Cochrane Reviews, German Cancer Foundation, Dutch Cancer Society, European Urology, Nature Reviews Urology, Journal of Urology, British Journal of Urology, World Journal of Urology, International Journal of Urology, Clinical Genitourinary Cancer, PLOS One, British Journal of Cancer, Asian Journal of Andrology, Annals of Transplantation, Egyptian Journal of Urology, Oncotarget, Diagnostic and Interventional Radiology, Case Reports in Urology, Expert Reviews in Anticancer Therapy Academic Awards: 2014 Awardee of the Maximillian-Nitze Prize (highest Prinze of the German Association of Urology, Düsseldorf/Germany 2011 Best Abstract Award of the Greek-German Association of Urology in Athens/Greece 2011 2nd Video Prize at the Annual Meething of the American Urological Association in Washington/D.C., USA 2011 3rd Video Prize at the Annual Meeting of the European Association of Urology in Vienna/Austria 2010 1st Video Prize at the Annual Meeting of the German Association of Urology in Düsseldorf/Germany 2010 Best Abstract Award at the World Congress on Controversies in Urology in Athens/Greece 2004 Travel Scholarship of the Germany Association of Neurogastroenterology 2004-2005 Awardee of German National Merit Foundation State doctorate: 2016 Professor of Urology, Eberhard-Karls Univesity, Tuebingen 2014 \\\\\\\"Venia legendi\\\\\\\" for Urology, Dept. of Urology, University Hospital Tuebingen: Doctoral thesis: 2006 Doctoral thesis, Dept. of General- and Visceral Surgery, University Hospital Tuebingen: Academic studies: 1999-2005: Medical School, Eberhard-Karls University, Tuebingen, Germany Tübingen, October 2nd, 2016